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“A STUDY OF VARIOUS FACTORS INFLUENCING CONSUMER BUYING PREFERENCES TOWARDS TOOTH BRUSH BRANDS AT PCMC AREA, PUNE”
SANTOSH SHINDE,AMOD MARKALE
Golden Research Thoughts , 2012, DOI: 10.9780/22315063
Abstract: The present day services scenario in FMCG sector have changed remarkably and it is often stated that the this sector in India are yet to standardize their service delivery and customers have often been left to their own individual discretion in respect of choice of tooth brush. The present study of 100 such customers throw light on specific factors that they look into while choosing a tooth brush brands. This study can influence the managements to appropriately strategies their management philosophies such that they do not lose ground in the long run. The study also suggests certain measures that the manufacturer of tooth brush brands can adopt in a liberalized and globalised set up of Fast moving consumer goods operations.
Respiratory-chain enzyme activities in isolated mitochondria of lymphocytes from patients with Parkinson′s disease: Preliminary study
Shinde Santosh,Pasupathy K
Neurology India , 2006,
Abstract: Background: Evidence suggests that mitochondrial dysfunction stimulates the production of reactive oxygen species (ROS) that promote neural cell death in stroke and in Parkinson′s disease. The sites of mitochondrial ROS production are not established but are generally believed to be located within the electron transport chain. Aims: We studied the mitochondrial respiratory chain enzymes function from human circulating lymphocytes. Setting and Design: Open study. Materials and Methods: Forty patients with Parkinson′s disease (PD) with 30 age-matched control subjects were selected in this study. The patients had received no treatment before the study was conducted. Statistical Analysis: The data from patients and controls were compared using two-tailed student′s t-test and values were expressed as means ± standard deviation (SD). Results: Respiratory complex I + III and IV activities were significantly lower (P < 0.001) in patients than in control subjects. Conclusions: The use of lymphocytes for investigating the respiratory chain enzymes provides an easy, noninvasive method to assess mitochondrial function in patients with PD. Furthermore, our study supports the hypothesis that a biochemical defect in the respiratory chain may be involved in the pathogenesis of PD.
MicroRNA Gene Interaction in Amyotrophic Lateral Sclerosis Dataset
Santosh Shinde,Utpal Bhadra
Dataset Papers in Science , 2014, DOI: 10.1155/2014/780726
Abstract: All microRNAs (miRNAs) in amyotrophic lateral sclerosis (ALS) study were collected from public databases such as miRBase, mir2Disease, and Human miRNA and Disease Database (HMDD). These miRNA datasets were used for target identification; these sets of miRNAs were expressed in brain specific parts of brain such as midbrain, cerebellum, frontal cortex, and hippocampus. Gene’s information and sequences were collected from NCBI and KEGG databases. All miRNAs were used for target prediction against 35 ALS associated genes. Three programs were used for target identification, namely, miRanda, TargetScan, and PicTar. The dataset contained information about miRNA targets sites identified by each program. Intersection studies of three programs such as miRanda versus TargetScan, miRanda versus PicTar, and TargetScan versus PicTar were carried out with all datasets. Target sites identified by each program were further explored for distribution of target sites across 35 genes in 5′ UTR, CDS, and 3′ UTR for miRNAs expressed in midbrain, cerebellum, frontal cortex, and hippocampus as predicted. Dataset was also used for calculation of multiplicity and coopretivity; this information was then used for construction of complex gene-microRNA interaction map. 1. Introduction Neurological disorders are major health problems in recent years and it is projected that the number of people affected by these disorders will double every 20 years [1]. The burden associated with these diseases is especially very high in low income and developing countries. The most assuring approaches must be used for rehabilitation and reduction of the burden of neurological disorders. This needs promising healthcare policies which will strengthen neurological care within the existing healthcare system. ALS is the most common neuromuscular disease which affects younger and older people of all races and ethnic background. It is caused due to mutations in SOD1 and other associated genes which lead to ALS-related motor neuron degeneration. There is no specific cure for ALS disease. However, FDA has approved first drug treatment for the disease riluzole (Rilutek), which is believed to reduce damage of motor neurons [2]. It increases survival in ALS patients, but it is not a very effective treatment for ALS patients. Thus there is a major challenge to search novel therapeutics for treatment of ALS; new promising technologies such as RNAi are the boon for healthcare. miRNAs are the small potent regulators which are effective noncoding RNA, which control almost 60% of human gene and several diseases.
Variation in Dose Measurement for Glycine Dosimeter
Santosh H. Shinde,T. Mukherjee
Journal of Scientific Review , 2011,
Abstract:
Glycine Pellet (Spectrophotometric Read-out) System: A New Routine Dosimeter for Routine Radiation Processing Dosimetry
Santosh H. Shinde,T. Mukherjee
Journal of Scientific Review , 2011,
Abstract:
Influence of Relative Humidity, Dose Rate and Dose Fractionation on Gamma Dose Response of Glycine Dosimetric System
Santosh H. Shinde,T. Mukherjee
Journal of Scientific Review , 2011,
Abstract:
Effect of Cesium–137 Gamma Rays and High-Energy Electrons on Dose Response of Glycine Dosimeter
Santosh H. Shinde,T. Mukherjee
Journal of Scientific Review , 2010,
Abstract: Glycine (50 mg / 10 mL FX) system can be used in the dose range of 500 to 4000 Gy for Cobalt-60 gamma rays. The energy dependency study for the glycine system was carried out by comparing its dose response for Cesium–137 gamma rays and 7 MeV electron beam with the dose response for Cobalt-60 gamma rays. It was found that for both the radiations viz.: Cesium-137 gamma rays and electrons, there is no significant change in dose response as compared with that for Cobalt-60.
Aleukemic leukemia cutis
Vishalakshi Vishwanath,Torsekar R,Shinde Santosh
Indian Journal of Dermatology, Venereology and Leprology , 2007,
Abstract: Aleukemic leukemia cutis has always been a dermatological curiosity. It is a rare condition characterized by the infiltration of skin by leukemic cells before their appearance in the peripheral blood or bone marrow. A 20 year old man had presented with nodular swelling on the scalp of 6 months duration along with cervical lymphadenopathy. Biopsy and immunohistochemistry revealed myeloid sarcoma. The initial presentation was aleukemic and repeated peripheral blood counts and marrow examinations were normal. However, the outcome was fatal within 3 months of diagnosis of cutaneous lesions.
A Complex Network of MicroRNAs Expressed in Brain and Genes Associated with Amyotrophic Lateral Sclerosis
Santosh Shinde,Neelima Arora,Utpal Bhadra
International Journal of Genomics , 2013, DOI: 10.1155/2013/383024
Abstract: Amyotrophic Lateral Sclerosis (ALS) is a rare neurological disease affecting mainly motor neurons and often leads to paralysis and death in extreme cases. For exploring the role of microRNAs in genes regulation in ALS disease, miRanda was employed for prediction of target sites of miRNAs expressed in various parts of brain and CNS on 35 genes associated with ALS. Similar search was conducted using TargetScan and PicTar for prediction of target sites in UTR only. 1456 target sites were predicted using miRanda and more target sites were found in UTR and CDS region as compared to UTR. 11 target sites were predicted to be common by all the algorithms and, thus, these represent the most significant sites. Target site hotspots were identified and were recognized as hotspots for multiple miRNAs action, thus, acting as favoured sites of action for the repression of gene expression. The complex interplay of genes and miRNAs brought about by multiplicity and cooperativity was explored. This investigation will aid in elucidating the mechanism of action of miRNAs for the considered genes. The intrinsic network of miRNAs expressed in nervous system and genes associated with ALS may provide rapid and effective outcome for therapeutic applications and diagnosis. 1. Introduction A complete coordination of brain signals and their functional execution in different body parts is often found in multicellular organisms. However, mechanism underlying such coordination between brain and body is still a mystery. How a trivial defect in the coordinated communication can lead to a disease has been a subject of study for many years. Neurological disorders are responsible for major proportion of the global burden of disease [1]. The mammoth rise in incidence of neurological disorders has led to initiatives for declaration of global epidemic. With the significant rise in number of cases of neurological disorders across the globe, it is postulated that no particular geographical region or age group is immune to these disorders. Among these, neurodegenerative disorders that are triggered by environmental and genetic factors are major cause of concern for aged population. Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, prion diseases, Amyotrophic Lateral Sclerosis, Huntington's disease, and various spinocerebellar ataxias account for significant morbidity. Progressive and slow degeneration of neurons as witnessed in these diseases leads to neuron dysfunction. The escalating cost of treatment and financial burden in terms of loss in disability adjusted life
SCREENING OF ANTICONVULSANT ACTIVITY OF KUSHMANDA FRUIT (BENINCASA HISPIDA THUMB) IN ALBINO RATS
Raghuveer,Santosh B,V. Nageswara Rao,Shinde Mahadev
International Research Journal of Pharmacy , 2012,
Abstract: The aim of the present study was to evaluate the anticonvulsant activity of juice and aqueous extract of Benincasa hispida Thumb fruit in Albino Rats. Two drug samples were prepared i.e. Benincasa hispida fruit juice and aqueous extract. MES Model was adopted to observe the seizure control activity of tested drug. Flexion, clonus, recovery time, duration of tonic hind leg extension and onset of stupor were observed. Preliminary Phytochemical analysis revealed presence of Steroids, Alkaloids, Starch, Hexosugars, Monosaccharide’s and Proteins. Swarasa (Juice) at the dose of 0.9 ml/200 gm of rat shows significant protection against the shock induced convulsions (Significant at the level of P<0.05). Aqueous extract at dose 100mg/200 gm of rat shown lesser protection compare to the Swarasa (Significant at the level P<0.05). Nasal and orbital bleeding is observed in control and standard group but it is absent in test groups. Study reveals Benincasa hispida fruit juice possesses anticonvulsant activity.
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